English to Russian Science Medical (general)

With over 112.5 million units donated globally every year and an average end-of-storage loss of potency of at least approximately 17% in current additives (calculated from posttransfusion recovery studies), novel storage additives still offer an actionable window of opportunity to significantly impact the field of transfusion medicine by improving RBC storage quality. Alterations of purine metabolism resulting from ATP consumption and breakdown into purines like hypoxanthine are markers of the metabolic age of RBCs. Decreases in the levels of nondeaminated purines cannot be corrected by additional adenine loading of storage additives. Activation of purine deaminases such as erythrocyte-specific adenosine monophosphate (AMP) deaminase 3 in turn results in potentially toxic by-products such as hypoxanthine.

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